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220005 CGP-37157 - CAS 75450-34-9 - Calbiochem

A cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC₅₀ = 360 nM).

CGP-37157 - CAS 75450-34-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one

Primary Target: Mitochondrial Na+/Ca2+ exchanger
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      75450-34-9C₁₅H₁₁Cl₂NOS
      Description
      OverviewA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
      Catalogue Number220005
      Brand Family Calbiochem®
      Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
      References
      ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
      Product Information
      CAS number75450-34-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₁₁Cl₂NOS
      Chemical formulaC₁₅H₁₁Cl₂NOS
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMitochondrial Na+/Ca2+ exchanger
      Primary Target IC<sub>50</sub>360 nM against mitochondrial Na+/Ca2+ exchanger
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      220005 0

      Documentation

      CGP-37157 - CAS 75450-34-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      CGP-37157 - CAS 75450-34-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      220005

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2013 JSW
      Synonyms7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
      DescriptionA cell-permeable benzothiazepine derivative of clonazepam that acts as a specific and potent inhibitor of the mitochondrial Na+/Ca2+ exchanger (IC50 = 360 nM). Enhances the export of Ca2+ from isolated mitochondria. Also reported to directly inhibit voltage-gated Ca2+ channels.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number75450-34-9
      Chemical formulaC₁₅H₁₁Cl₂NOS
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml). Dilute in Ca2+-free buffer just prior to use.
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesJornot, L., et al. 1999. J. Cell Sci. 112, 1013.
      Babcock, D.F., et al. 1997. J. Cell Biol. 136, 833.
      Baron. K.T., and Thayer, S.A. 1997. Eur. J. Pharmacol. 340, 295.
      Griffiths, E.J., et al. 1997. Cell Calcium 21, 321.
      White, R.J., and Reynolds, I.J. 1996, J. Neurosci. 16, 5688.
      Cox, D.A., et al. 1993. J. Cardivasc. Pharmacol. 21, 595.
      Cox, D.A., and Matlib, M.A. 1993. J. Biol. Chem. 268, 938.