203715 Sigma-AldrichBQ-610 - Calbiochem
A highly selective ETA receptor antagonist (IC₅₀ = 20 nM) that attenuates ET-induced reduction in cardiac output.
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Aperçu
Replacement Information |
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Tableau de caractéristiques principal
Empirical Formula |
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C₃₆H₄₇N₇O₆ |
Description | |
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Overview | This product has been discontinued. A highly selective ETA receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50 = 28.2 nM). BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in porcine aortic smooth muscle membrane assay. |
Catalogue Number | 203715 |
Brand Family | Calbiochem® |
Product Information | |
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ATP Competitive | N |
Form | White lyophilized powder |
Formulation | Supplied as an ammonium salt. |
Hill Formula | C₃₆H₄₇N₇O₆ |
Chemical formula | C₃₆H₄₇N₇O₆ |
Hygroscopic | Hygroscopic |
Reversible | N |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | ETA receptor antagonist |
Primary Target IC<sub>50</sub> | 20 nM as ETA receptor antagonist that attenuates ET-induced reduction in cardiac output |
Purity | ≥90% by HPLC |
Physicochemical Information | |
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Cell permeable | N |
Peptide Sequence | Homopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4 |
Dimensions |
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Materials Information |
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Toxicological Information |
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Safety Information according to GHS |
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Safety Information |
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Product Usage Statements |
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Packaging Information |
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Supplemental Information |
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Specifications |
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Global Trade Item Number | |
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Référence | GTIN |
203715 | 0 |
Documentation
BQ-610 - Calbiochem FDS
Titre |
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BQ-610 - Calbiochem Certificats d'analyse
Titre | Numéro de lot |
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203715 |
Références bibliographiques
Aperçu de la référence bibliographique |
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Beyer, M.E., et al. 1999. Hypertension 33, 145. Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021. Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487. Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761. Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685. |