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189291 Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem

Atorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      134523-03-8[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Description
      Overview

      This product has been discontinued.



      A cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
      Catalogue Number189291
      Brand Family Calbiochem®
      Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
      References
      ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
      Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
      Law, M.R., et al. 2003. BMJ 326, 1423.
      Youssef, S., et al. 2002. Nature 420, 78.
      Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
      Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
      Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
      Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
      Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
      Product Information
      CAS number134523-03-8
      FormWhite powder
      Hill Formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationAtorvastatin, Calcium Salt, CAS 134523-03-8, is a cell-permeable, highly potent, and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver).
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      189291 0

      Documentation

      Atorvastatin, Calcium Salt - CAS 134523-03-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      189291

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
      Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
      Law, M.R., et al. 2003. BMJ 326, 1423.
      Youssef, S., et al. 2002. Nature 420, 78.
      Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
      Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
      Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
      Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
      Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision25-May-2012 JSW
      Synonyms(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt,
      DescriptionA cell-permeable ring-opened pentasubstituted pyrrolyl-dihydroxyheptanoate compound that acts as a highly potent and competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (IC50 = 7.5 nM in rat liver microsomes). Reduces cholesterol synthesis and increases the expression LDL receptors in hepatocytes. Exhibits anti-inflammatory and anti-oxidant properties. Acts as a hypotensive agent that acts by enhancing flow mediated dilation. Shown to overcome carboplatin resistance in non-small-cell lung carcinomas possibly by suppressing Akt activity and upregulating TIMP-1.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number134523-03-8
      Chemical formula[(C₃₃H₃₄FN₂O₅)2Ca•3H₂O]1/2
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml; clear, colorless solution) or Methanol (10 mg/ml; clear, colorless solution) or Ethanol (2 mg/ml; clear, colorless solution). Not soluble in H₂O.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, J., et al. 2012. Int. J. Biochem. Cell Biol., in press.
      Tycinska, A.M., et al. 2011. Arch. Med. Sci. 7, 955.
      Law, M.R., et al. 2003. BMJ 326, 1423.
      Youssef, S., et al. 2002. Nature 420, 78.
      Burnett, J.R., et al. 1998. Arterioscler. Thromb. Vasc. Biol. 18, 1906.
      Bustos, C., et al. 1998. J. Am. Coll. Cardiol. 32, 2057.
      Bocan, T.M.A., et al. 1992. Biochimica et Biophysica Acta 1123, 133.
      Roth, B.D., et al. 1991. J. Med. Chem. 34, 463.
      Shaw, M.K., et al. 1990. Biochem. Biophys. Res. Commun. 170, 726.