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178385 Apocynin - CAS 498-02-2 - Calbiochem

A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase.

Apocynin - CAS 498-02-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V

Primary Target: NADPH oxidase
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178385
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
498-02-2C₉H₁₀O₃

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178385-1GM
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      Description
      OverviewA cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM).
      Catalogue Number178385
      Brand Family Calbiochem®
      Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
      References
      ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
      Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
      Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
      Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
      van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
      Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.
      Product Information
      CAS number498-02-2
      ATP CompetitiveN
      FormWhite to off-white powder
      Hill FormulaC₉H₁₀O₃
      Chemical formulaC₉H₁₀O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNADPH oxidase
      Purity≥98% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSAM8800000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      178385-1GM 04055977222463

      Documentation

      Apocynin - CAS 498-02-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Apocynin - CAS 498-02-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      178385

      Références bibliographiques

      Aperçu de la référence bibliographique
      Abid, M.R., et al. 2000. FEBS Lett. 486, 252.
      Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
      Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
      Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
      van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
      Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.

      Brochure

      Titre
      Pathways and Biomarkers of Oxidative Stress
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-February-2018 JSW
      Synonyms4-Hydroxy-3-methoxyacetophenone, Acetovanillone, NADPH Oxidase Inhibitor V, NOX Inhibitor V
      DescriptionA cell-permeable, anti-inflammatory phenol that acts as a potent and selective inhibitor of NADPH oxidase. Also blocks peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through the activation of AP-1. Shown to prevent phagocytosis of myelin by macrophages (10 mM).
      FormWhite to off-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number498-02-2
      RTECSAM8800000
      Chemical formulaC₉H₁₀O₃
      Structure formulaStructure formula
      Purity≥98% by GC
      SolubilityDMSO (10 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Irritant
      Merck USA index14, 741
      ReferencesAbid, M.R., et al. 2000. FEBS Lett. 486, 252.
      Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932.
      Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235.
      Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776.
      van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67.
      Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3.