Millipore Sigma Vibrant Logo

04-294 Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5

Detect phosho-erbB2/Her2 (Tyr1112) using this Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5 validated for use in ELISA & WB.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: ERBB2, HER2, HER-2, NGL, herstatin, erbB-2, C-erbB-2, NEU, TKR1, p185erbB2, HER-2/neu UniProt Number: P04626
View Products on Sigmaaldrich.com
04-294
100 µg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      Offres spéciales

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Offres spéciales

      100% Performance Guaranteed

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ca, H, M, RELISA, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-294
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5
      References
      Product Information
      FormatPurified
      Control
      • Includes EGF treated SKOV-3 lysate as a positive control
      PresentationLyophilized in 2X PBS containing 0.09% sodium azide, PEG, and sucrose.
      Quality LevelMQ100
      Applications
      ApplicationDetect phosho-erbB2/Her2 (Tyr1112) using this Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5 validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide encompassing the surrounding amino acids of Tyr1112 in human erbB2/Her2
      Clone19G5
      HostMouse
      SpecificityRecognizes phosphorylated domain of erbB2/Her2 on Tyrosine 1112
      IsotypeIgG1
      Species Reactivity
      • Canine
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
      Gene Symbol
      • ERBB2
      • HER2
      • HER-2
      • NGL
      • herstatin
      • erbB-2
      • C-erbB-2
      • NEU
      • TKR1
      • p185erbB2
      • HER-2/neu
      Modifications
      • Phosphorylation
      Purification MethodSubsequent thiophilic adsorption and size exclusion chromatography
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.
      SIZE: 1255 amino acids; 137910 Da
      SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
      SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
      Molecular Weight185 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at -20°C from date of shipment. Reconstitute prior to use. Reconstitute with 1 mL H2O for 15 min at room temperature. Reconstituted aliquots should be stored frozen at -80°C. Thawed aliquots may be stored at 4°C for up to 3 months. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      04-294 04053252367526

      Documentation

      Anti-phosho-erbB2/Her2 (Tyr1112) Antibody, clone 19G5 Certificats d'analyse

      TitreNuméro de lot
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 (Mouse monoclonal IgG1) - 2454690 2454690
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 (Mouse monoclonal IgG1) 2967801
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 (Mouse monoclonal IgG1) 2943145
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 - 2383445 2383445
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 - 0216S0102 0216S0102
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 - 2914554 2914554
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 -2586411 2586411
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 -2617718 2617718
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 -2638898 2638898
      Anti-phosho-erbB2/Her2 (Tyr1112), clone 19G5 -2817742 2817742
      Show more

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2.
      Klapper, L N, et al.
      Cancer Res., 60: 3384-8 (2000)  1999

      Afficher le résumé       		10910043 10910043

      Produits & Applications associés

      Related Products

      Référence Description  
      04-293 Anti-phospho-erbB2 (Thr686) Antibody, clone 7F8 Prix & Disponibilité
      06-229 Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody Prix & Disponibilité
      06-562 Anti-erbB-2/HER-2 Antibody Prix & Disponibilité
      16-235 Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 488 Prix & Disponibilité
      16-236 Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Alexa Fluor® 555 Prix & Disponibilité
      MABE320 Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1 Prix & Disponibilité
      MABE330 Anti-c-ErbB2/c-Neu Antibody, clone 3B5 Prix & Disponibilité

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies