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ABN895 Anti-TDP-43 Antibody

This Anti-TDP-43 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of TDP-43.

Anti-TDP-43 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: TARDBP, TDP43 UniProt Number: Q13148
ABN895
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN895
      DescriptionAnti-TDP-43 Antibody
      Alternate Names
      • TAR DNA-binding protein 43
      • TDP-43
      Background InformationTAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease and Alzheimer's disease.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.02% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-TDP-43 Antibody is validated for use in Western Blotting_x000D_ and Immunocytochemistry for the detection of TDP-43.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis (ICC): 5 μg/mL from a representative lot detected TDP-43 in HeLa cells.
      Biological Information
      ImmunogenTDP43 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human TDP43.
      EpitopeNear C-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • TARDBP
      • TDP43
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~30 and ~45 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis (WB): 1 μg/mL of this antibody detected TDP-43 in HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABN895 04055977174670

      Produits & Applications associés

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies