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AB4350 Anti-PRDM14 Antibody

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AB4350
100 µL  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB4350
      DescriptionAnti-PRDM14 Antibody
      Alternate Names
      • PR domain zinc finger protein 14
      • PR domain-containing protein 14
      Background InformationPR domain proteins (PRDMs) have been associated with many types of human cancers. PRDM14 was found to be up-regulated in breast cancer cells. The expression of PRDM14 to breast cancer cells actually increased cell proliferation and decreased the effect of chemotherapeutic drugs, while down-regulation of PRDM14 did the opposite. In addition to breast cancer, PRDM14 has recently been linked to non-small cell lung cancer development. PRDM14 also seems to play a role in the preservation of the self-renewal of human embryonic stem cells and transcriptional regulation.
      Product Information
      FormatAffinity Purified
      Control
      • Human lung tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl and 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-PRDM14 Antibody is validated for use in WB for the detection of PRDM14.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to the N-terminus of human PRDM14.
      EpitopeN-terminus
      HostRabbit
      SpecificityThis antibody recognizes the N-terminus of PRDM14.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummarySummary: The PR domain is a protein-protein interaction module of about 100 amino acids. PR domain-containing proteins, such as PRDM14, are often involved in transcriptional regulation (Jiang and Huang, 2000 [PubMed 10668202]).[supplied by OMIM].
      Gene Symbol
      • PRDM14
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: May be involved in transcriptional regulation.

      SUBCELLULAR LOCATION: Nucleus (potential).

      SEQUENCE SIMILARITIES: Contains 6 C2H2-type zinc fingers. Contains 1 SET domain.
      Molecular Weight~62 kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human lung tissue lysate.

      Western Blot Analysis: A 1:1000 dilution of this antibody detected PRDM14 in 10 µg of human lung tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Référence GTIN
      AB4350 04053252421747