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AB3538P Anti-Monocarboxylate Transporter 1 Antibody

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AB3538P
50 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3538P
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Monocarboxylate Transporter 1 Antibody
      Alternate Names
      • MCT1
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.1% BSA.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Monocarboxylate Transporter 1 Antibody is validated for use in ELISA, WB for the detection of Monocarboxylate Transporter 1.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1-5 μg/mL using ECL.
      ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well.
      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenA 15 amino acid peptide sequence near the C-terminus of human MCT1 (Gerhart et al. 1997; Knott et al. 1999; Takanaga et al. 1995; Carpenter et al. 1996; Koehler-Stec et al. 1998; Yoon et al. 1999; Halestrap & Price 1999).
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes human Monocarboxylate Transporter 1 (MCT1). The immunogen shows no significant sequence homology with MCT2-8.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe SLC16A1 gene encodes a monocarboxylate transporter (MCT1) that mediates the movement of lactate and pyruvate across cell membranes Import and export of these substrates by tissues such as erythrocytes, muscle, intestine, and kidney are ascribed largely to the action of a proton-coupled MCT (Garcia et al., 1994 [PubMed 8124722]).[supplied by OMIM]
      Gene Symbol
      • SLC16A1
      • MCT
      • FLJ36745
      • MGC44475
      • MCT1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P53985 # Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
      SIZE: 500 amino acids; 53958 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in normal and in cancer cells.
      DISEASE: SwissProt: P53985 # Defects in SLC16A1 are the cause of symptomatic deficiency in lactate transport (SDLT) [MIM:245340]; also known as erythrocyte lactate transporter defect. Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals.
      SIMILARITY: SwissProt: P53985 ## Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      Référence GTIN
      AB3538P 04053252730528