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MAB1587 Anti-Glutamate Transporter Antibody, neuronal, clone 4D6.2

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MAB1587
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1587
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Glutamate Transporter Antibody, neuronal, clone 4D6.2
      Alternate Names
      • EAAT3
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.02M Phosphate buffer, 0.25M NaCl, pH 7.6 with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Glutamate Transporter Antibody, neuronal, clone 4D6.2 is an antibody against Glutamate Transporter for use in IH & WB.
      Key Applications
      • Immunohistochemistry
      • Western Blotting
      Application NotesWestern blot: 1-2 μg/mL

      Immunohistochemistry: 1-2 μg/mL

      Optimal working dilutions must be determined by end user.



      EAAC1 is approximately 66-70kDa; the protein can form homomultimers during preparation as well, thus often times large 200-220kDa bands can also be seen.
      Biological Information
      ImmunogenC-terminus peptide (KDKSDTISFTQTSQF) (Catalog Number AG372).
      Clone4D6.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityGlutamate Transporter EAAC1.

      Based on protein sequence the antibody is expected to react with mouse, bovine and rabbit.
      IsotypeIgG1
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC1A1
      • EAAC1
      • EAAT3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P43005 # Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).
      SIZE: 524 amino acids; 57100 Da
      SUBUNIT: Interacts with ARL6IP5/PRAF3 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
      PTM: Glycosylated.
      DISEASE: SwissProt: P43005 # Defects in SLC1A1 may be a cause of dicarboxylicamino aciduria [MIM:222730]; also known as glutamate-aspartate transport defect. This is as defect in renal and probably intestinal transport of glutamic and aspartic acids and is associated with moderate hyperprolinemia.
      SIMILARITY: SwissProt: P43005 ## Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to six months.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      MAB1587 04053252318764