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AB9682 Anti-Dardarin Antibody

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AB9682
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MELISA, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB9682
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Dardarin Antibody
      Alternate Names
      • LRRK2 Leucine-rich repeat kinase 2
      References
      Product Information
      FormatSerum
      Control
      • Brain tissue
      PresentationRabbit Serum. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Dardarin Antibody detects level of Dardarin & has been published & validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesWestern blot: 1:5,000-1:10,000 on mouse brain extract.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from rat LRRK2.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes LRRK2 [leucine-rich repeat kinase 2, Dardarin]. By Western blot the antibody recognizes a band at ~240 kDa in mouse brain extract. An additional band at ~130-140 kDa can also be seen. On human brain lysate the antibody recognizes a band at ~150 kDa.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8.
      Gene Symbol
      • LRRK2
      • AURA17
      • RIPK7
      • ROCO2
      • dardarin
      • FLJ45829
      • PARK8
      • DKFZp434H2111
      • Dardarin
      • EC 2.7.11.1
      Purification MethodUnpurified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q5S007 # Probable protein kinase whose role is not yet known. May play a role in the phosphorylation of proteins central to Parkinson disease. May also have GTPase activity.
      SIZE: 2527 amino acids; 286058 Da
      SUBUNIT: Interacts with PARK2.
      SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Localized in the cytoplasm and associated with cellular membrane structures. Associates with the mitochondrial outer membrane.
      TISSUE SPECIFICITY: Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas.
      DISEASE: SwissProt: Q5S007 # Defects in LRRK2 are the cause of Parkinson disease 8 (PARK8) [MIM:607060, 168600]. Parkinson disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years, although early-onset cases (before 50 years) are known. PD generally arises as a sporadic condition but is occasionally inherited as a simple mendelian trait. Although sporadic and familial PD are very similar, inherited forms of the disease usually begin at earlier ages and are associated with atypical clinical features. PD is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK8 is an autosomal-dominant late- onset parkinsonism, characterized by onset from 50 to 65 years, with slow progression and relatively benign course.
      SIMILARITY: SwissProt: Q5S007 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 16 LRR (leucine-rich) repeats. & Contains 1 Miro domain. & Contains 1 protein kinase domain.
      Molecular Weight286 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB9682 04053252281709

      Documentation

      Anti-Dardarin Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Dardarin Antibody Certificats d'analyse

      TitreNuméro de lot
      RABBIT ANTI- LRRK2 -2547168 2547168
      RABBIT ANTI- LRRK2 -2603227 2603227
      RABBIT ANTI- LRRK2 POLYCLONAL ANTIBODY - 2199573 2199573

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
      Biskup, S; Moore, DJ; Rea, A; Lorenz-Deperieux, B; Coombes, CE; Dawson, VL; Dawson, TM; West, AB
      BMC neuroscience  8  102  2007

      Afficher le résumé
      18045479 18045479
      Leucine-rich repeat kinase 2 associates with lipid rafts.
      Hatano, T; Kubo, S; Imai, S; Maeda, M; Ishikawa, K; Mizuno, Y; Hattori, N
      Human molecular genetics  16  678-90  2007

      Afficher le résumé
      17341485 17341485

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies