124012 Sigma-AldrichAkt Inhibitor V, Triciribine - CAS 35943-35-2 - Calbiochem
Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3.
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Synonymes: NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2
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Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 35943-35-2 | C₁₃H₁₆N₆O₄ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 124012-10MG |
|
Flacon en verre | 10 mg |
|
— | |
| 124012-1MG |
|
Ampoule plast. | 1 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3. It does not inhibit known upstream activators of Akt, i.e. PI3K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥ 60% in cell proliferation at 20 µM) and in vivo (≥ 80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.). Also available in InSolution™ format (Cat. No. 124038). |
| Catalogue Number | 124012 |
| Brand Family | Calbiochem® |
| Synonyms | NSC 154020, TCN, Akt/PKB Signaling Inhibitor-2, API-2 |
| References | |
|---|---|
| References | Karst, A., et al. 2006. Cancer Res. 66, 9225. Yang, L., et al. 2004. Cancer Res. 64, 4394. |
| Product Information | |
|---|---|
| CAS number | 35943-35-2 |
| ATP Competitive | N |
| Form | Solid |
| Hill Formula | C₁₃H₁₆N₆O₄ |
| Chemical formula | C₁₃H₁₆N₆O₄ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Akt Inhibitor V, Triciribine, CAS 35943-35-2, is a cell-permeable, selective, reversible inhibitor of the cellular phosphorylation/activation of Akt1/2/3. |
| Biological Information | |
|---|---|
| Primary Target | Akt1, Akt 2, Akt3 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information according to GHS | |
|---|---|
| RTECS | RY8455000 |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 124012-10MG | 04055977205640 |
| 124012-1MG | 04055977205633 |