124011 Sigma-AldrichAkt Inhibitor IV - CAS 681281-88-9 - Calbiochem
Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
More>> Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Less<<Produits recommandés
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Aperçu
Tableau de caractéristiques principal
CAS # | Empirical Formula |
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681281-88-9 | C₃₁H₂₇IN₄S |
Prix & Disponibilité
Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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124011-1MG |
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Flacon en verre | 1 mg |
|
— | |
124011-5MG |
|
Ampoule plast. | 5 mg |
|
— |
Description | |
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Overview | A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available. |
Catalogue Number | 124011 |
Brand Family | Calbiochem® |
References | |
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References | Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
Product Information | |
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CAS number | 681281-88-9 |
ATP Competitive | N |
Form | Yellow solid |
Hill Formula | C₃₁H₂₇IN₄S |
Chemical formula | C₃₁H₂₇IN₄S |
Hygroscopic | Hygroscopic |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Référence | GTIN |
124011-1MG | 04055977206357 |
124011-5MG | 04055977205626 |