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110123 Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem

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Synonymes: AKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid

Primary Target: 5-lipoxygenase
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      67416-61-9C₃₂H₄₈O₅
      Description
      Overview

      This product has been discontinued.



      A cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥ 10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
      Catalogue Number110123
      Brand Family Calbiochem®
      SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
      References
      ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
      Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
      Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
      Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
      Product Information
      CAS number67416-61-9
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₂H₄₈O₅
      Chemical formulaC₃₂H₄₈O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target5-lipoxygenase
      Primary Target IC<sub>50</sub>1.5 µM against 5-lipoxygenase in rat PMNLs
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      110123 0

      Documentation

      Acetyl-11-keto-β-Boswellic Acid, Boswellia serrata - CAS 67416-61-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      110123

      Références bibliographiques

      Aperçu de la référence bibliographique
      Syrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
      Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
      Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
      Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-May-2010 JSW
      SynonymsAKβBA, 3-O-Acetyl-11-keto-β-Boswellic Acid
      DescriptionA cell-permeable pentacyclic triterpene of the ursane type that displays anti-tumor and anti-inflammatory properties. Shown to block the phosphorylation and degradation of IκBα and inhibit NF-κB-mediated gene transcription in chemoresistant, androgen-independent PC-3 prostate cancer cells (~10 µM). Mobilizes intracellular Ca2+ and stimulates the activation of p42/44 and p38 MAPKs (~30 µM in human PMN) and increases the formation of reactive oxygen species. Also reported to induce apoptosis and act as a non-redox, non-competitive inhibitor of 5-lipoxygenase (IC50 = 1.5 µM in rat PMNLs), and topoisomerase I (≥10 µM in calf thymus). When complexed with γ-cyclodextrin to facilitate its delivery, AKβBA has been demonstrated to exhibit in vivo efficacy in tumor growth and inhibition.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number67416-61-9
      Chemical formulaC₃₂H₄₈O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesSyrovets, T., et al. 2005. J. Biol. Chem. 280, 6170.
      Altmann, A., et al. 2004. Br. J. Pharmacol. 141, 223.
      Altmann, A., et al. 2002. Biochem. Biophys. Res. Commun. 290, 185.
      Hoernlein, R.F., et al. 1999. J. Pharmacol. Exp. Ther. 288, 613.