171272 Sigma-AldrichAMPK Activator VI, RSVA314 - CAS 316130-82-2 - Calbiochem
The AMPK Activator VI, RSVA314 modulates the biological activity of AMPK. This small molecule/inhibitor is primarily used for Biochemicals applications.
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Synonymes: RSVA314, AMPK Signaling Activator VI
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Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 316130-82-2 | C₁₈H₂₁N₃O₃ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 171272-10MG |
|
Flacon en verre | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell permeable hydrozide that activates AMPK indirectly via a CaMKKβ-dependent pathway similar to resveratrol (Cat. No. 554325), which results in the phosphorylation of Thr-172 on the AMPKα2 subunit. This activator promotes lysosomal amyloid-β degradation in 3 cell lines nearly 40 times more potently than resveratrol with an IC50 of 1-2 µM. Treatment with RSVA314 at 1-3 µM results in a dose-dependent inhibition of the phosphorylation of 3 proteins downstream from mTOR activation including p70S6K, eukaryotic elongation factor 2 kinase (eEF2K), and S6 ribosomal protein, and promotes a robust increase in the phosphorylation of the protein raptor at Ser-792 in western blots. At the same concentrations, it elicits a strong, dose-dependent conversion of the light chain 3 (LC3) protein, a marker involved with autophagy induction, from LC3-I and LC3-II, also in western blots. |
| Catalogue Number | 171272 |
| Brand Family | Calbiochem® |
| Synonyms | RSVA314, AMPK Signaling Activator VI |
| References | |
|---|---|
| References | Vingtdeux, V., et al. 2011. FASEB J. 25, 219. |
| Product Information | |
|---|---|
| CAS number | 316130-82-2 |
| Form | Yellow solid |
| Hill Formula | C₁₈H₂₁N₃O₃ |
| Chemical formula | C₁₈H₂₁N₃O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | >90% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 171272-10MG | 04055977207217 |