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658430 AG 99

AG 99 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Tyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide

658430
  
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      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.

      Please refer to our complete listing of protein tyrosine kinase inhibitors for possible alternatives. Please read the alternative product documentation carefully and contact technical service if you need additional information.





      A cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 10 µM) and EGF-dependent cell proliferation. Inhibits EGFR phosphorylation and ERK1 and ERK2 activities.
      Catalogue Number658430
      Brand Family Calbiochem®
      SynonymsTyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide
      References
      ReferencesPai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Product Information
      CAS number118409-59-9
      FormOff-white solid
      Hill FormulaC₁₀H₈N₂O₃
      Chemical formulaC₁₀H₈N₂O₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetepidermal growth factor (EGF) receptor tyrosine kinase
      Primary Target IC<sub>50</sub>10 µM
      Secondary targetEGF-dependent cell proliferation, EGFR phosphorylation and ERK1 and ERK2 activities
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      658430 0

      Documentation

      AG 99 Certificats d'analyse

      TitreNuméro de lot
      658430

      Références bibliographiques

      Aperçu de la référence bibliographique
      Pai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-January-2010 RFH
      SynonymsTyrphostin A46, Tyrphostin B40, α-Cyano-(3,4-dihydroxy)cinnamide
      DescriptionA cell-permeable, reversible, and substrate competitive inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 10 µM) and EGF-dependent cell proliferation.
      FormOff-white solid
      CAS number118409-59-9
      Chemical formulaC₁₀H₈N₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesPai, R., et al. 1998. Gastroenterology, 114, 706. Gazit, A., et al. 1991. J. Med. Chem. 34, 1896. Gazit, A., et al. 1989. J. Med. Chem. 32, 2344.