499610 Sigma-Aldrich(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem
(5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).
More>> (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: TAK1 Inhibitor
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 66018-38-0 | C₁₉H₂₂O₇ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 499610-1MG |
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Flacon en verre | 1 mg |
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| Description | |
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| Overview | A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control. |
| Catalogue Number | 499610 |
| Brand Family | Calbiochem® |
| Synonyms | TAK1 Inhibitor |
| Product Information | |
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| CAS number | 66018-38-0 |
| Form | White solid |
| Hill Formula | C₁₉H₂₂O₇ |
| Chemical formula | C₁₉H₂₂O₇ |
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| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥97% by HPLC |
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| Safety Information according to GHS |
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| Safety Information | |
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| S Phrase | S: 22-24/25-36/37/39 Do not breathe dust. Avoid contact with skin and eyes. Wear suitable protective clothing, gloves and eye/face protection. |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 499610-1MG | 04055977199277 |
Documentation
(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem FDS
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(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 499610 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Windheim, M., et al. 2007. Biochem. J. 404, 179. Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970. Safwat, N., et al. 2005. Endocrinology 146, 4814. Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485. Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799. |
Brochure
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| Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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