Millipore Sigma Vibrant Logo

100069 17-DMAG - CAS 467214-21-7 - Calbiochem

17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).

17-DMAG - CAS 467214-21-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG

Primary Target: 17-DMAG
View Products on Sigmaaldrich.com
100069
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
467214-21-7C₃₂H₄₈N₄O₈ • HCl

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
100069-500UG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 500 μg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen), and displays excellent bioavailability and aqueous solubility.
      Catalogue Number100069
      Brand Family Calbiochem®
      SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
      References
      ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
      Product Information
      CAS number467214-21-7
      ATP CompetitiveN
      FormPurple solid
      Hill FormulaC₃₂H₄₈N₄O₈ • HCl
      Chemical formulaC₃₂H₄₈N₄O₈ • HCl
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application17-DMAG, CAS 467214-21-7, is a more potent antitumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM).
      Biological Information
      Primary Target17-DMAG
      Primary Target IC<sub>50</sub>GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      100069-500UG 04055977226188

      Documentation

      17-DMAG - CAS 467214-21-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      100069

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2022 JSW
      SynonymsNSC 707545, 17-Desmethoxy-17-N,N-dimethylaminoethylamino-geldanamycin, HCl, 17-N,N-Dimethylaminoethylamino-17-demethoxy-geldanamycin, HCl, 17DMAG
      DescriptionA cell-permeable, water soluble, potent anti-tumor analog of 17-AAG (Cat. No. 100068) that binds to the ATPase site of human Hsp90α with high affinity (GI50 = 51 nM for 17-DMAG vs. 120 nM for 17-AAG in the NCI 60-cell panel in vitro activity screen).
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number467214-21-7
      Chemical formulaC₃₂H₄₈N₄O₈ • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTian, Z.Q., et al. 2004. Bioorg. Med. Chem. 12, 5317.
      Jez, J.M., et al. 2003. Chem. Biol. 10, 361.
      Egorin, M.J., et al. 2002. Cancer Chemother. Pharmacol. 49, 7.