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385581 11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

The 11beta-HSD1 Inhibitor, 10j, also referenced under CAS 1009373-58-3, controls the biological activity of 11beta-HSD1. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

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385581
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
1009373-58-3C₂₆H₃₃BrN₂O₃

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385581-10MG
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      Description
      OverviewA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
      Catalogue Number385581
      Brand Family Calbiochem®
      References
      ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
      Product Information
      CAS number1009373-58-3
      FormWhite solid
      Hill FormulaC₂₆H₃₃BrN₂O₃
      Chemical formulaC₂₆H₃₃BrN₂O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      385581-10MG 04055977190298

      Documentation

      11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      385581

      Références bibliographiques

      Aperçu de la référence bibliographique
      Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-April-2011 RFH
      DescriptionA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
      FormWhite solid
      CAS number1009373-58-3
      Chemical formulaC₂₆H₃₃BrN₂O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSL (100 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.