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505227 (-)-Cytisine - CAS 485-35-8 - Calbiochem

(-)-Cytisine - CAS 485-35-8 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine

Primary Target: nAChR
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505227
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
485-35-8C₁₁H₁₄N₂O

Prix & Disponibilité

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5.05227.0001
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      Description
      OverviewA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
      Catalogue Number505227
      Brand Family Calbiochem®
      SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
      References
      ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
      West, R., 2011, N. Engl. J. Med. 365, 1193.
      Happe, K., et al., 1994. Neurosci. 62, 929.
      Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
      Product Information
      CAS number485-35-8
      FormPale yellow solid
      Hill FormulaC₁₁H₁₄N₂O
      Chemical formulaC₁₁H₁₄N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnAChR
      Primary Target K<sub>i</sub>2, 5890, 480, 329, and 492 nM at &alpha
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 35-36/37/38

      Causes severe burns.
      Irritating to eyes, respiratory system and skin.
      S PhraseS: 22-26-28.1-36/37/39-46-63

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      After contact with skin, wash immediately with plenty of water.
      Wear suitable protective clothing, gloves and eye/face protection.
      If swallowed, seek medical advice immediately and show this container or label.
      In case of accident by inhalation: remove casualty to fresh air and keep at rest.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.05227.0001 04055977263503

      Documentation

      (-)-Cytisine - CAS 485-35-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
      West, R., 2011, N. Engl. J. Med. 365, 1193.
      Happe, K., et al., 1994. Neurosci. 62, 929.
      Reavill, C. et al., 1990. Neuropharmacol. 29, 619.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2013 JSW
      SynonymsnAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
      DescriptionA potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
      FormPale yellow solid
      CAS number485-35-8
      Chemical formulaC₁₁H₁₄N₂O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesChen, Y., et al., 2012. Br J Pharmacol. 165, 1006.
      West, R., 2011, N. Engl. J. Med. 365, 1193.
      Happe, K., et al., 1994. Neurosci. 62, 929.
      Reavill, C. et al., 1990. Neuropharmacol. 29, 619.