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505875 (+)-Bicuculline - CAS 485-49-4 - Calbiochem

(+)-Bicuculline - CAS 485-49-4 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: GABAA Receptor Antagonist, Bicuculline

Primary Target: GABAA
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505875
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
485-49-4C₂₀H₁₇NO₆

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5.05875.0001
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      Description
      OverviewA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
      Catalogue Number505875
      Brand Family Calbiochem®
      SynonymsGABAA Receptor Antagonist, Bicuculline
      References
      ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
      Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
      Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
      Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.
      Product Information
      CAS number485-49-4
      FormPale yellow solid
      Hill FormulaC₂₀H₁₇NO₆
      Chemical formulaC₂₀H₁₇NO₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGABAA
      Primary Target IC<sub>50</sub>740 Nm
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 23-24-28-46

      Toxic by inhalation.
      Toxic in contact with skin.
      Very toxic if swallowed.
      May cause heritable genetic damage.
      S PhraseS: 22-28.1-36/37/39

      Do not breathe dust.
      After contact with skin, wash immediately with plenty of water.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.05875.0001 04055977263114

      Documentation

      (+)-Bicuculline - CAS 485-49-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      (+)-Bicuculline - CAS 485-49-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      505875

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ueno, S., et al. 1997. J. Neurosci. 17, 625.
      Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
      Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
      Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.

      Brochure

      Titre
      New Products Flyer- Feb 2014 - Vol 1
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsGABAA Receptor Antagonist, Bicuculline
      DescriptionA potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.
      FormPale yellow solid
      CAS number485-49-4
      Chemical formulaC₂₀H₁₇NO₆
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic
      ReferencesUeno, S., et al. 1997. J. Neurosci. 17, 625.
      Uchida, I., et al. 1996. Eur. J. Pharmacol. 307, 89.
      Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol. 230, 187.
      Robert K.A., et al. 1993. Cardiovasc. Pharmacol. 21, 156.