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506181 p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5 - Calbiochem

p75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic

Primary Target: Blocker of MAG- and Nogo-induced inhibition of neurite outgrowth
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506181
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Overview

Key Spec Table

Empirical Formula
C₁₅₀H₂₂₇N₅₇O₃₂S₂

Pricing & Availability

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506181-500UG
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      Description
      OverviewThe p75NTR inhibitor Pep5 (Cat. No. 506180) is made cell-permeable by fusing it with the N-terminal protein transduction domain sequence (11 amino acids) from HIV protein TAT. Shown to act as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in both DRG (dorsal root ganglion) and postnatal cerebellar neurons. A potential therapeutic agent against inhibition of regeneration in the central nervous system.
      Catalogue Number506181
      Brand Family Calbiochem®
      SynonymsTAT-Pep5, H-YGRKKRRQRRR-CFFRGGFFNHNPRYC-OH, Cyclic
      References
      ReferencesYamashita, T., and Tohyama, M. 2003. Nat. Neurosci. 6, 461.
      Schwarze, S.R., et al. 1999. Science 285, 1569.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
      Chemical formulaC₁₅₀H₂₂₇N₅₇O₃₂S₂
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Applicationp75NTR Signaling Inhibitor, Cell-permeable, TAT-Pep5, acts as an effective blocker of MAG- and Nogo-induced inhibition of neurite outgrowth in dorsal root ganglion & postnatal cerebellar neurons.
      Biological Information
      Primary TargetBlocker of MAG- and Nogo-induced inhibition of neurite outgrowth
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH₂N-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Cys¹²-Phe-Phe-Arg-Gly-Gly-Phe-Phe-Asn-His-Asn-Pro-Arg-Tyr-Cys²⁶-OH
      disulfide bond (12-26)
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      506181-500UG 04055977272413