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676494 VEGF Inhibitor, Je-11 - Calbiochem

VEGF Inhibitor, Je-11 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII

Primary Target: Binds to VEGF and blocks its interaction with VEGFR-2
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₈₈H₂₇₃N₄₉O₅₇
      Description
      Overview

      This product has been discontinued.



      A dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/Flk-1) comprising residues 247 - 261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 and inhibits the proliferation and migration of cultured microvascular endothelial cells. Binds to VEGF and blocks its interaction with VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC).
      Catalogue Number676494
      Brand Family Calbiochem®
      Synonyms(RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
      References
      ReferencesPiossek, C., et al. 1999. J. Biol. Chem. 274, 5612.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₈₈H₂₇₃N₄₉O₅₇
      Chemical formulaC₁₈₈H₂₇₃N₄₉O₅₇
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetBinds to VEGF and blocks its interaction with VEGFR-2
      Primary Target IC<sub>50</sub>500 nM on extracellular VEGFR-2 fragments; 30 µM on HUVEC
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide Sequence(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      676494 0

      Documentation

      VEGF Inhibitor, Je-11 - Calbiochem Certificates of Analysis

      TitleLot Number
      676494

      References

      Reference overview
      Piossek, C., et al. 1999. J. Biol. Chem. 274, 5612.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-September-2008 RFH
      Synonyms(RTELNVGIDFNWEYPAS)₂K-NH₂, VEGFR Tyrosine Kinase Inhibitor XI, VEGFR2 Kinase Inhibitor XII
      DescriptionA dimerized peptide derived from the third Ig-like domain of the human vascular endothelial growth factor receptor-2 (VEGFR-2 or KDR/FLK-1) comprising residues 247-261. Acts as an inhibitor of VEGF-stimulated autophosphorylation of VEGFR-2 (IC50 = 500 nM on extracellular VEGFR-2 fragments; IC50 = 30 µM on HUVEC).
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈₈H₂₇₃N₄₉O₅₇
      Peptide Sequence(H-Arg-Thr-Glu-Leu-Asn-Val-Gly-Ile-Asp-Phe-Asn-Trp-Glu-Tyr-Pro-Ala-Ser)₂-Lys-NH₂
      Purity≥90% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesPiossek, C., et al. 1999. J. Biol. Chem. 274, 5612.