616379 Sigma-AldrichToxin A, Clostridium difficile - Calbiochem
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Overview
Description | |
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Overview | This product has been discontinued. A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositol 4,5-bisphosphate. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells. |
Catalogue Number | 616379 |
Brand Family | Calbiochem® |
Synonyms | Enterotoxin |
References | |
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References | Mackay, D.J. and Hall, A. 1998. J. Biol. Chem. 273, 20685. Mahida, Y.R., et al. 1996. Gut 38, 337. Wilkins, T.D. and Lyerly, D.M. 1996. Trends Microbiol. 4, 49. |
Product Information | |
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ATP Competitive | N |
Form | Solid |
Formulation | Lyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5. |
Reversible | N |
Quality Level | MQ100 |
Physicochemical Information | |
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Cell permeable | N |
Safety Information according to GHS | |
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RTECS | KA8080200 |
Global Trade Item Number | |
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Catalogue Number | GTIN |
616379 | 0 |