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648492 TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem

The TRPM4 inhibitor, 9-Phenanthrol, also referenced under CAS 484-17-3, controls the biological activity of TRPM4. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Phenanthren-9-ol, 9-Hydroxyphenanthrene

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648492
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
484-17-3C₁₄H₁₀O

Pricing & Availability

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648492-50MG
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      Description
      OverviewA cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
      Catalogue Number648492
      Brand Family Calbiochem®
      SynonymsPhenanthren-9-ol, 9-Hydroxyphenanthrene
      References
      ReferencesGrand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
      Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
      Product Information
      CAS number484-17-3
      FormBrown solid
      Hill FormulaC₁₄H₁₀O
      Chemical formulaC₁₄H₁₀O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      648492-50MG 04055977185072

      Documentation

      TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      TRPM4 inhibitor, 9-Phenanthrol - CAS 484-17-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      648492

      References

      Reference overview
      Grand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
      Simard, C., 2012. Brit. Journ. Pharm.165, 2354.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-July-2012 JSW
      SynonymsPhenanthren-9-ol, 9-Hydroxyphenanthrene
      DescriptionA cell permeable hydroxytricyclic derivative that acts as a specific and reversible inhibitor of transient receptor potential melastatin 4 (TRPM4) (IC50 = 20 µM in HEK293 cells). Does not affect TRPM5 and cystic fibrosis transmembrane conductance regulators (CFTR) channels. Decreases the occurrence of early after depolarizations (EAD) and exhibits an anti-arrhythmic effect that is independent of the action of protein kinase A. Shown to abolish NMDA-induced burst firing in dopaminergic neurons. Does not affect K+ currents at ~10 µM, but at higher concentration (~100 µM) it reversibly reduces K+ currents.
      FormBrown solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number484-17-3
      Chemical formulaC₁₄H₁₀O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesGrand, T., et al. 2008. Brit. Journ. Pharm.153, 1697.
      Simard, C., 2012. Brit. Journ. Pharm.165, 2354.