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616430 TGF-α, Human, Recombinant, E. coli

TGF-α, Human, Recombinant, E. coli MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Transforming Growth Factor-α

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616430
  
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      Overview

      Replacement Information

      Key Spec Table

      Purity
      ≥97% by SDS-PAGE
      Description
      Overview

      This product has been discontinued.



      Recombinant, human transforming growth factor-α expressed in E. coli. Plays an important role in cell-cell adhesion and cell growth and differentiation. Reported to play a role in the development of hormonal insensitivity in estrogen-receptor-positive breast cancers.
      Catalogue Number616430
      Brand Family Calbiochem®
      SynonymsTransforming Growth Factor-α
      References
      ReferencesNicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
      Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
      Massague, J. 1990. J. Biol. Chem. 265, 21393.
      Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
      Schreiber, A.B., et al. 1986. Science 232, 1250.
      Tam, J.P. 1985. Science 229, 673.
      Derynck, R., et al. 1984. Cell 38, 327.
      Product Information
      CAS number105186-99-0
      FormLyophilized
      FormulationLyophilized from 30% acetonitrile, 0.1% TFA.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀= 0.1-0.4 ng/ml as measured by the ability to stimulate ³H-thymidine incorporation in the mouse fibroblast cell line Balb/3T3
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤100 pg/µg TGF-α
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Canadian export regulations Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616430 0

      Documentation

      TGF-α, Human, Recombinant, E. coli SDS

      Title

      Safety Data Sheet (SDS) 

      TGF-α, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      616430

      References

      Reference overview
      Nicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
      Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
      Massague, J. 1990. J. Biol. Chem. 265, 21393.
      Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
      Schreiber, A.B., et al. 1986. Science 232, 1250.
      Tam, J.P. 1985. Science 229, 673.
      Derynck, R., et al. 1984. Cell 38, 327.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-September-2008 RFH
      SynonymsTransforming Growth Factor-α
      DescriptionRecombinant, human transforming growth factor-α expressed in E. coli. Plays an important role in cell-cell adhesion and cell growth and differentiation. Reported to play a role in the development of hormonal insensitivity in estrogen-receptor-positive breast cancers.
      FormLyophilized
      FormulationLyophilized from 30% acetonitrile, 0.1% TFA.
      CAS number105186-99-0
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤100 pg/µg TGF-α
      Biological activityED₅₀= 0.1-0.4 ng/ml as measured by the ability to stimulate ³H-thymidine incorporation in the mouse fibroblast cell line Balb/3T3
      SolubilityReconstitute to a concentration of ≥10 µg/ml with sterile 10 mM acetic acid containing ≥0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long-term storage or refrigerate (4°C) for short-term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for up to 1 month at 4°C or for up to 3 months at -70°C.
      Toxicity Standard Handling
      ReferencesNicholson, R.I., et al. 1994. Cancer Res. 54, 1684.
      Anklesaria, P., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 3289.
      Massague, J. 1990. J. Biol. Chem. 265, 21393.
      Watanabe, S., et al. 1987. Proc. Natl. Acad. Sci. USA 84, 1258.
      Schreiber, A.B., et al. 1986. Science 232, 1250.
      Tam, J.P. 1985. Science 229, 673.
      Derynck, R., et al. 1984. Cell 38, 327.

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors