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579051 TAPI-1 - CAS 171235-71-5 - Calbiochem

TAPI-1, CAS 171235-71-5, is a structural analog of TAPI-0 with similar in vitro efficacy for the inhibition of MMPs and TACE. Blocks the shedding of several cell surface proteins.

TAPI-1 - CAS 171235-71-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1

Primary Target: MMPs and TACE
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579051
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Overview

Key Spec Table

CAS #Empirical Formula
171235-71-5C₂₆H₃₇N₅O₅

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579051-1MG
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      Description
      OverviewA structural analog of TAPI-0 (Cat. No. 579050) with similar in vitro efficacy for the inhibition of MMPs and TACE (TNF-α converting enzyme/ADAM17). TAPI-1 also blocks the shedding of several cell surface proteins such as IL-6 receptor, p60 TNF receptor, and p80 TNF receptor. Blocks constitutive (IC50 = 8.09 µM) and muscarinic receptor-stimulated (IC50 = 3.61 µM) sAAPα release in HEK 293 cells expressing M3 muscarinic receptors. A 10 mM (500 µg/100 µl) solution of TAPI-1 (Cat. No. 579050) in DMSO is also available.
      Catalogue Number579051
      Brand Family Calbiochem®
      SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-1
      References
      ReferencesSlack, B.E., et al. 2001. Biochem. J. 357, 787.
      Vincent, B., et al. 2001. J. Biol. Chem. 276, 37743.
      Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
      Crowe, P.D., et al. 1995. J. Exp. Med. 181, 1205.
      Mullberg, J., et al. 1995. J. Immunol. 155, 5198.
      Mohler, K.M., et al. 1994. Nature 370, 218.
      Product Information
      CAS number171235-71-5
      ATP CompetitiveN
      DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
      FormWhite solid
      Hill FormulaC₂₆H₃₇N₅O₅
      Chemical formulaC₂₆H₃₇N₅O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetMMPs and TACE
      Primary Target IC<sub>50</sub>8.09 µM and 3.61 µM blocking constitutive and muscarinic receptor-stimulated sAAPα release in HEK 293 cells expressing M3 muscarinic receptors, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      579051-1MG 04055977265361