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12-140 Src Substrate Peptide

Src Substrate Peptide primarily used in Kinase Assays.

Src Substrate Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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12-140
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-140
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSrc Substrate Peptide
      OverviewSynthetic peptide (KVEKIGEGTYGVVYK) corresponding to amino acids 6-20 of p34cdc2.
      References
      Product Information
      PresentationLyophilized powder
      Quality LevelMQ100
      Applications
      ApplicationSrc Substrate Peptide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
      Gene Symbol
      • SRC
      • ASV
      • c-src
      • p60-Src
      • SRC1
      • c-SRC
      • pp60c-src
      Protein TargetSrc
      Target Sub-FamilyTK
      UniProt Number
      UniProt SummarySIZE: 536 amino acids; 59835 Da
      SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.
      PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.
      SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
      Molecular Weight1670 Daltons (1.67 kDa)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated in a protein kinase assay as a substrate for Src (p60c-src), (14-117) or Lck (p56lck), active (14-379).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      12-140 04053252337550

      Documentation

      Src Substrate Peptide SDS

      Title

      Safety Data Sheet (SDS) 

      Src Substrate Peptide Certificates of Analysis

      TitleLot Number
      16-184 - 2298361 2298361
      Src Substrate Peptide 3291283
      Src Substrate Peptide - 2148509 2148509
      Src Substrate Peptide - 2439213 2439213
      Src Substrate Peptide - 2439655 2439655
      Src Substrate Peptide - 16332 16332
      Src Substrate Peptide - 17808 17808
      Src Substrate Peptide - 18651 18651
      Src Substrate Peptide - 1984870 1984870
      Src Substrate Peptide - 20579 20579
      Show more

      References

      Reference overviewApplicationPub Med ID
      Contraction regulation of Akt in rat skeletal muscle
      Sakamoto, K., et al
      J Biol Chem, 277:11910-7 (2002)  2002

      		Immunoblotting (Western)11809761 11809761
      Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells
      Szekeres, C. K., et al
      J Biol Chem, 275:38831-41 (2000)  2000

      		Immunoblotting (Western)10952974 10952974
      RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells
      Chang, B. Y., et al
      Mol Cell Biol, 18:3245-56 (1998)  1998

      		Kinase Assay9584165 9584165

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      Categories

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      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates