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567630 Sodium Salicylate - CAS 54-21-7 - Calbiochem

A cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein.

Sodium Salicylate - CAS 54-21-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Salicylic Acid, Na, NaSal

Primary Target: TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
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567630
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Overview

Key Spec Table

CAS #Empirical Formula
54-21-7C₇H₅O₃ · Na

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567630-5GM
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      Description
      OverviewA cell-permeable, non-steroidal anti-inflammatory agent that interferes with TNF-induced NF-κB activation by inhibiting phosphorylation and subsequent degradation of the IκB-α protein. Selectively inhibits TNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases. Also inhibits TNF-induced activation of JNK. Induces apoptosis via p38 kinase activation. Inhibits COX-2 and inducible NOS (iNOS) transcription independently of NF-κB activation.
      Catalogue Number567630
      Brand Family Calbiochem®
      SynonymsSalicylic Acid, Na, NaSal
      References
      ReferencesSchwenger, P., et al. 1998. Mol. Cell. Biol. 18, 78.
      Mitchell, J.A., et al. 1997. Mol. Pharmacol. 51, 907.
      Schwenger, P., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 2869.
      Farivar, R.S. and Brecher, P. 1996. J. Biol. Chem. 271, 31585.
      Schwenger, P., et al. 1996. J. Biol. Chem. 271, 8089.
      Product Information
      CAS number54-21-7
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₇H₅O₃ · Na
      Chemical formulaC₇H₅O₃ · Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetTNF-induced activation of p42 (ERK2) and p44 (ERK1) MAP kinases
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSVO5075000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 24/25

      Avoid contact with skin and eyes.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      567630-5GM 04055977266825