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567060 Siomycin A, Streptomyces sioyaensis - Calbiochem

Siomycin A, Streptomyces sioyaensis, CAS 12656-09-6, is a cell-permeable macrocyclic antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NSC 285116, FOXM1 Inhibitor II

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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₇₁H₈₁N₁₉O₁₈S₅
      Description
      OverviewA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
      Catalogue Number567060
      Brand Family Calbiochem®
      SynonymsNSC 285116, FOXM1 Inhibitor II
      References
      ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
      Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
      Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
      Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
      Product Information
      FormWhite solid
      Hill FormulaC₇₁H₈₁N₁₉O₁₈S₅
      Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
      Quality LevelMQ100
      Applications
      ApplicationSiomycin A, Streptomyces sioyaensis, CAS 12656-09-6, is a cell-permeable macrocyclic antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding.
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 22-24/25-36/37-45

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      567060 0

      Documentation

      Siomycin A, Streptomyces sioyaensis - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Siomycin A, Streptomyces sioyaensis - Calbiochem Certificates of Analysis

      TitleLot Number
      567060

      References

      Reference overview
      Priller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
      Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
      Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
      Lentzen, G., et al. 2003. Chem. Biol. 10, 769.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-November-2011 JSW
      SynonymsNSC 285116, FOXM1 Inhibitor II
      DescriptionA cell-permeable thiostrepton (Cat. No. 598226) family macrocyclic peptide antibiotic that inhibits bacterial protein synthesis (IC50 = 250 nM) by interfering with rRNA binding. Shown to inhibit mammalian FoxM1 (forkhead box M1) function in C3 cells by negatively regulating its transcriptional activity (IC50 ≤5 µM), phosphorylation, as well as mRNA (>60% reduction at 10 µM) and protein (>90% reduction at 20 µM) abundance. Selectively induces apoptosis in SV40-transformed MRC-5 human fetal lung fibroblasts, but not the non-transformed wild-type cells.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₇₁H₈₁N₁₉O₁₈S₅
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesPriller, M., et al. 2011. Clin. Cancer Res. 17, 6791.
      Radhakrishnan, S.K., et al. 2006. Cancer Res. 66, 9731.
      Erdal, H., et al. Proc. Natl. Acad. Sci. USA 102, 192.
      Lentzen, G., et al. 2003. Chem. Biol. 10, 769.