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557324
Sigma-AldrichRiluzole - CAS 1744-22-5 - Calbiochem
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels.
More>>A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Less<<
Riluzole - CAS 1744-22-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease).
Inhibits glutamate release and blocks Na+ channels
Purity
≥97% by HPLC
Physicochemical Information
Cell permeable
Y
Contaminants
Heavy metals: ≤20 ppm
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECS
DL2830000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code
Ambient Temperature Only
Toxicity
Toxic
Hazardous Materials Attention:
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage
+2°C to +8°C
Protect from Light
Protect from light
Do not freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Riluzole - CAS 1744-22-5 - Calbiochem Certificates of Analysis
Title
Lot Number
557324
References
Reference overview
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400. Schiefer, J., et al. 2002. Mov. Disord.17, 748. Mizuta, I., et al. 2001. Neurosci. Lett.310, 117. Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196. Mizoule, J., et al. 1985. Neuropharmacology24, 767.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington's disease (HD).
Form
White to off-white solid
Intert gas (Yes/No)
Packaged under inert gas
CAS number
1744-22-5
RTECS
DL2830000
Chemical formula
C₈H₅F₃N₂OS
Purity
≥97% by HPLC
Contaminants
Heavy metals: ≤20 ppm
Solubility
DMSO (40 mg/ml) or HCl (0.1N)
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Toxic
Merck USA index
14, 8223
References
Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400. Schiefer, J., et al. 2002. Mov. Disord.17, 748. Mizuta, I., et al. 2001. Neurosci. Lett.310, 117. Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196. Mizoule, J., et al. 1985. Neuropharmacology24, 767.
