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14-612M RIPK2 Protein, active, 250 µg

Active, human RIPK2, amino acids 1-299, for use in Kinase Assays.

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14-612M
250 µg  Also available in 10 μg size (cat#14-612) and in bulk (cat#14-612-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-612M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRIPK2 Protein, active, 250 µg
      Overviewhuman RIPK2, amino acids 1-299
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, human RIPK2, amino acids 1-299, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceN-terminal His6-tagged, recombinant, human RIPK2 expressed by baculovirus in Sf21 insect cells
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.
      Gene Symbol
      • RIPK2
      • RIP2
      • GIG30
      • RICK
      • CARDIAK
      • CARD3
      • CCK
      • RIP-2
      Protein TargetRIPK2
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyTKL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O43353 # Activates pro-caspase-1 and pro-caspase-8. Potentiates CASP8-mediated apoptosis. Activates NF-kappa-B.
      SIZE: 540 amino acids; 61195 Da
      SUBUNIT: Binds to CFLAR/CLARP and CASP1 via their CARD domains. Binds to BIRC3/c-IAP1 and BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5 and TRAF6. May be a component of both the TNFRSF1A and TNRFSF5/CD40 receptor complex.
      SUBCELLULAR LOCATION: Cytoplasm (Probable).
      TISSUE SPECIFICITY: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
      PTM: Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
      SIMILARITY: SwissProt: O43353 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 CARD domain. & Contains 1 protein kinase domain.
      Molecular Weight37.8kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of MBP
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-612) and in bulk (cat#14-612-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-612M 04053252924293

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-612 RIPK2 Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases