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539483 Proteinase 3, Human Neutrophils

Proteinase 3, Human Neutrophils MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Myoblastin, PR3, PR3 Ag, PR III

539483
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Native, human proteinase 3 purified from neutrophils. A serine protease with proinflammatory properties, expressed mainly in neutrophils. Proteinase 3 is the antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, frequently found in Wegener's granulomatosis.
      Catalogue Number539483
      Brand Family Calbiochem®
      SynonymsMyoblastin, PR3, PR3 Ag, PR III
      References
      ReferencesUehara, A., et al. 2007. Mol. Immunol. 44, 3552.
      Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
      Clin. Nephrol. 2005 Dec;64(6):453-9.
      von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
      Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
      Specks, U., et al. 1996. FEBS Lett. 390, 265.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze one µmol methoxysuccinyl-Ala-Ala-Pro-Val-<i>p</i>NA per min at 37°C, pH 7.5.
      FormLiquid
      FormulationIn 150 mM NaCl, 50 mM sodium acetate, 0.1% Triton® X-100 detergent, pH 6.0.
      Applications
      Biological Information
      Purity≥96% by SDS-PAGE
      SourcePrepared from neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      539483 0

      Documentation

      Proteinase 3, Human Neutrophils Certificates of Analysis

      TitleLot Number
      539483

      References

      Reference overview
      Uehara, A., et al. 2007. Mol. Immunol. 44, 3552.
      Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
      Clin. Nephrol. 2005 Dec;64(6):453-9.
      von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
      Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
      Specks, U., et al. 1996. FEBS Lett. 390, 265.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-February-2009 JSW
      SynonymsMyoblastin, PR3, PR3 Ag, PR III
      DescriptionNative, human proteinase 3 purified from neutrophils. A serine protease with proinflammatory properties, expressed mainly in neutrophils. Proteinase 3 is the antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, frequently found in Wegener's granulomatosis.
      FormLiquid
      FormulationIn 150 mM NaCl, 50 mM sodium acetate, 0.1% Triton® X-100 detergent, pH 6.0.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from neutrophils that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥96% by SDS-PAGE
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze one µmol methoxysuccinyl-Ala-Ala-Pro-Val-pNA per min at 37°C, pH 7.5.
      Storage Avoid freeze/thaw
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Standard Handling
      ReferencesUehara, A., et al. 2007. Mol. Immunol. 44, 3552.
      Villegas-Mendez, A., et al. 2007. J. Thromb. Haemost. 5, 980.
      Clin. Nephrol. 2005 Dec;64(6):453-9.
      von Vietinghoff S., et al. 2005. Clin. Nephrol. 64, 453.
      Wiesner, O., et al. 2005. FEBS Lett. 579, 5305.
      Specks, U., et al. 1996. FEBS Lett. 390, 265.