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529570 PPM-18

PPM-18 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-Benzoylamino-1,4-naphthoquinone

Primary Target: iNOS
529570
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      65240-86-0C₁₇H₁₁NO₃
      Description
      Overview

      This product has been discontinued.



      Please refer to our complete listing of nitric oxide synthase inhibitors for possible alternatives.






      A novel, cell-permeable, anti-inflammatory agent that inhibits the expression of inducible nitric oxide synthase (iNOS; IC50 = ~ 5 µM). Acts by blocking the activation of NF-κB in vitro and in vivo. Does not directly affect the enzymatic activities of iNOS or eNOS.
      Catalogue Number529570
      Brand Family Calbiochem®
      Synonyms2-Benzoylamino-1,4-naphthoquinone
      References
      ReferencesDavis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
      Yu, S.M., et al. 1997. Biochem. J. 328, 363.
      Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.
      Product Information
      CAS number65240-86-0
      FormYellow-orange solid
      Hill FormulaC₁₇H₁₁NO₃
      Chemical formulaC₁₇H₁₁NO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetiNOS
      Primary Target IC<sub>50</sub>5 mM
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      529570 0

      Documentation

      PPM-18 Certificates of Analysis

      TitleLot Number
      529570

      References

      Reference overview
      Davis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
      Yu, S.M., et al. 1997. Biochem. J. 328, 363.
      Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-April-2008 RFH
      Synonyms2-Benzoylamino-1,4-naphthoquinone
      DescriptionA cell-permeable naphthoquinone derivative that inhibits the expression of iNOS (IC50 ~5 µM) by blocking the activation of NF-κB in vitro and in vivo. Does not directly affect the enzymatic activities of iNOS or eNOS. Also prevents the dissociation of NF-κB/IκB-α complex and acts as a potent anti-inflammatory and anti-sepsis agent.
      FormYellow-orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number65240-86-0
      Chemical formulaC₁₇H₁₁NO₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or CH₃CN (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDavis, M.E., et al. 2004. J. Biol. Chem. 279, 163.
      Yu, S.M., et al. 1997. Biochem. J. 328, 363.
      Lien, J.-C., et al. 1996. Chem. Pharm. Bull. 44, 1181.