505892 Sigma-AldrichPKR Inhibitor III, 7DG CAS 26927-01-5 - Calbiochem
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Primary Target:
PKR
MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, Double-stranded RNA-dependent Protein Kinase Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 26927-01-5 | C₂₆H₃₀O₅ |
| Description | |
|---|---|
| Overview | A cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IκK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IκBβ degradaion (20 µM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10 µM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16 (Cat. Nos. 527450 & 527451), but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment. |
| Catalogue Number | 505892 |
| Brand Family | Calbiochem® |
| Synonyms | Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, Double-stranded RNA-dependent Protein Kinase Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin |
| References | |
|---|---|
| References | Hett, E.C., et al. 2013. Nat. Chem. Biol. 9, 398. |
| Product Information | |
|---|---|
| CAS number | 26927-01-5 |
| Form | Pale yellow solid |
| Hill Formula | C₂₆H₃₀O₅ |
| Chemical formula | C₂₆H₃₀O₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | PKR |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 505892 | 0 |