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526521 PIM1 Inhibitor III

The PIM1 Inhibitor III controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

PIM1 Inhibitor III MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PIM1
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526521
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₂₈H₂₃N₅O₅Ru
      Description
      OverviewThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
      Catalogue Number526521
      Brand Family Calbiochem®
      References
      ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
      Product Information
      ATP CompetitiveN
      DeclarationSold for research purposes only, pursuant to an agreement with University of Pennsylvania.
      FormPurple solid
      Hill FormulaC₂₈H₂₃N₅O₅Ru
      Chemical formulaC₂₈H₂₃N₅O₅Ru
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPIM1
      Primary Target IC<sub>50</sub>0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      526521 0

      Documentation

      PIM1 Inhibitor III SDS

      Title

      Safety Data Sheet (SDS) 

      PIM1 Inhibitor III Certificates of Analysis

      TitleLot Number
      526521

      References

      Reference overview
      Bergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-January-2008 JSW
      DescriptionThe racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).
      FormPurple solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₈H₂₃N₅O₅Ru
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (6 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesBergman, H. and Meggers, E., 2006. Org. Lett. 8, 5465.