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526520 PIM1 Inhibitor II

PIM1 Inhibitor II MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine

Primary Target: PIM1
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526520
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      491871-58-0C₁₈H₁₁BrN₂O₂
      Description
      Overview

      This product has been discontinued.



      A pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 > 20 µM).
      Catalogue Number526520
      Brand Family Calbiochem®
      Synonyms3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
      References
      ReferencesCheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.
      Product Information
      CAS number491871-58-0
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₈H₁₁BrN₂O₂
      Chemical formulaC₁₈H₁₁BrN₂O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPIM1
      Primary Target IC<sub>50</sub>50 nM against PIM1 kinase
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      526520 0

      Documentation

      PIM1 Inhibitor II Certificates of Analysis

      TitleLot Number
      526520

      References

      Reference overview
      Cheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone, 2-Hydroxy-3-cyano-4-phenyl-6-(3-bromo-6-hydroxyphenyl)pyridine
      DescriptionA pyridone compound that acts as an ATP-competitive inhibitor of PIM1 kinase (IC50 = 50 nM) with excellent selectivity over PIM2 and MEK1/2 (IC50 >20 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number491871-58-0
      Chemical formulaC₁₈H₁₁BrN₂O₂
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCheney, I. W., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1679.