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528111 PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem

The PI 3-Kα Inhibitor IV, also referenced under CAS 1188890-32-5, controls the biological activity of PI 3-Kα. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV

Primary Target: PI 3-Kα
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528111
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1188890-32-5C₁₆H₁₅N₃O₂S • 2HCl

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      Description
      OverviewA cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-kinases (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
      Catalogue Number528111
      Brand Family Calbiochem®
      Synonyms3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
      References
      ReferencesHayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.
      Product Information
      CAS number1188890-32-5
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₆H₁₅N₃O₂S • 2HCl
      Chemical formulaC₁₆H₁₅N₃O₂S • 2HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPI 3-Kα
      Primary Target IC<sub>50</sub>2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      528111-5MG 04055977270525

      Documentation

      PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PI 3-Kα Inhibitor IV - CAS 1188890-32-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      528111

      References

      Reference overview
      Hayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.

      Posters

      Title
      Human Kinome & InhibitorSelect™ Libraries
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2011 RFH
      Synonyms3-(4-Morpholinothieno[3,2-d]pyrimidin-2-yl)phenol, 2HCl, PI 3-K Inhibitor IV
      DescriptionA cell-permeable morpholino-thienopyrimidine compound that acts as a potent and isoform-selective inhibitor of PI 3-Ks (IC50 = 2 nM, 16 nM, 660 nM, and 220 nM for p110α, p110β p110γ, and PI 3-K C2β, respectively) and inhibits non-PI 3-K kinases only at much higher concentrations (IC50 ≥ 3.4 µM for Cdk2/E, KDR, PKA, and PKCα). Shown to inhibit cell proliferation (IC50 = 580 nM) and serum-stimulated Akt phosphorylation (IC50 <3 µM) in A375 melanoma cells.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1188890-32-5
      Chemical formulaC₁₆H₁₅N₃O₂S • 2HCl
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesHayakawa, M., et al. 2006. Bioorg. Med. Chem. 14, 6847.