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481411 NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem

The NF-κB Activation Inhibitor III, also referenced under CAS 380623-76-7, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368

Primary Target: TNF-α-stimulated NF-κB activation and upregulation of MMP-9
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481411
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
380623-76-7C₁₀H₅ClN₄O₅S

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481411-5MG
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      Description
      OverviewA cell-permeable thiazoloamide compound that inhibits TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
      Catalogue Number481411
      Brand Family Calbiochem®
      Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
      References
      ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
      Product Information
      CAS number380623-76-7
      ATP CompetitiveN
      FormLight yellow amorphous solid
      Hill FormulaC₁₀H₅ClN₄O₅S
      Chemical formulaC₁₀H₅ClN₄O₅S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α-stimulated NF-κB activation and upregulation of MMP-9
      Primary Target IC<sub>50</sub>Effective concentration: 10 µM for complete inhibition of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      481411-5MG 04055977183719

      Documentation

      NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NF-κB Activation Inhibitor III - CAS 380623-76-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      481411

      References

      Reference overview
      Lee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-August-2008 RFH
      Synonyms3-Chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide, SM-7368
      DescriptionA cell-permeable inhibitor of TNF-α-stimulated NF-κB activation and subsequent upregulation of MMP-9 in HT1080 cells (complete inhibition at 10 µM). The inhibition of MMP-9 upregulation correlates with a concomitant inhibition of TNF-α-dependent cell invasion. Does not affect TNF-α-induced AP-1 activity. The cellular target appears to be downstream of p38 activation.
      FormLight yellow amorphous solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number380623-76-7
      Chemical formulaC₁₀H₅ClN₄O₅S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesLee, H.Y., et al. 2005. Biochem. Biophys. Res. Commun. 336, 716.