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479830 NBI-31772 - CAS 374620-70-9 - Calbiochem

NBI-31772 - CAS 374620-70-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: [1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]

Primary Target: Human insulin-like growth factor-I binding proteins (IGFBPs).
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      374620-70-9C₁₇H₁₁NO₇
      Description
      Overview

      This product has been discontinued.



      We are offering NBI 31772 hydrate (Cat. No. N8289) as a possible alternative. Please read the alternative product documentation carefully and contact technical service if you need additional information.






      A non-peptide ligand that exhibits high-affinity (Ki ~ 1 - 17 nM) towards all six human insulin-like growth factor-I binding proteins (IGFBPs). Displaces insulin-like growth factor-I (IGF-I) from the IGF-I:IGFBP complex in 3T3 fibroblasts; however, it does not interact with the IGF receptors.
      Catalogue Number479830
      Brand Family Calbiochem®
      Synonyms[1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
      References
      ReferencesChen, C., et al. 2001. J. Med. Chem. 44, 4001.
      Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.
      Product Information
      CAS number374620-70-9
      ATP CompetitiveN
      FormGreenish-yellow solid
      Hill FormulaC₁₇H₁₁NO₇
      Chemical formulaC₁₇H₁₁NO₇
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetHuman insulin-like growth factor-I binding proteins (IGFBPs).
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      479830 0

      Documentation

      NBI-31772 - CAS 374620-70-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      NBI-31772 - CAS 374620-70-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      479830

      References

      Reference overview
      Chen, C., et al. 2001. J. Med. Chem. 44, 4001.
      Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms[1-(3ʹ,4ʹ-Dihydroxybenzoyl)-6,7-dihydroxyisoquinoline-3-carboxylic Acid]
      DescriptionA non-peptide ligand derived from the transformation of L-3,4-dihydroxy-phenylalanine that exhibits high affinity binding to all six human insulin-like growth factor-I binding proteins (IGFGPs) (Ki = 3.36 nM for IGFBP-1, 1.18 nM for IGFBP-2, 5.64 nM for IGFBP-3, 1.54 nM for IGFBP-4, 3.90 nM for IGFBP-5, and 16.6 nM for IGFBP-6). Inhibits insulin-like growth factor (IGF-I) induced cell proliferation in 3T3 fibroblasts through the displacement of IGF-I from the IGF-I:GFBP complex. However, it does not interact with IGF receptors.
      FormGreenish-yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number374620-70-9
      Chemical formulaC₁₇H₁₁NO₇
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesChen, C., et al. 2001. J. Med. Chem. 44, 4001.
      Liu, X.J., et al. 2001. J. Biol. Chem. 276, 32419.