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110110 N-Acetyl-S-farnesyl-L-cysteine

N-Acetyl-S-farnesyl-L-cysteine MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AFC

110110
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      Exhibits high affinity for S-farnesylcysteine methyl transferase (Km = 20 µM) thereby inhibiting the COOH-terminal methylation of protein in cell-free extracts and in whole cells. An inhibitor of β2-integrin-induced actin polymerization (IC50 = 5.5 µM). Known to block the fMLP-induced release of superoxides in human neutrophils (IC50 = 15 µM). Also inhibits carboxyl methylation of p21 platelet Rap1 and the γ-subunit of transducin.
      Catalogue Number110110
      Brand Family Calbiochem®
      SynonymsAFC
      References
      ReferencesMolony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.
      Product Information
      CAS number135304-07-3
      FormClear oil
      Hill FormulaC₂₀H₃₃NO₃S
      Chemical formulaC₂₀H₃₃NO₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetβ2-integrin-induced actin polymerization
      Primary Target IC<sub>50</sub>5.5 µM
      Secondary targetKnown to block the fMLP-induced release of superoxides in human neutrophils (IC₅₀ = 15 µM)
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      110110 0

      Documentation

      Operational Excellence Dossier

      Title

      N-Acetyl-S-farnesyl-L-cysteine Certificates of Analysis

      TitleLot Number
      110110

      References

      Reference overview
      Molony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-March-2011 JSW
      SynonymsAFC
      DescriptionExhibits high affinity for S-farnesylcysteine methyl transferase (Km = 20 µM), inhibiting the C-terminal methylation of protein in cell-free extracts and in whole cells. Known to block the fMLP-induced release of superoxides in human neutrophils (IC50 = 15 µM). Also inhibits carboxyl methylation of p21 platelet rap1 and the γ-subunit of transducin.
      FormClear oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number135304-07-3
      Chemical formulaC₂₀H₃₃NO₃S
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (25 mg/ml) or Ethanol (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesMolony, L., et al. 1996. Biochem. Biophys. Res. Commun. 223, 612. Ding, J., et al. 1994. J. Biol. Chem. 269, 16837. Philip, M.R., et al. 1993. Science 259, 977. Huzoor-Akbar, et al. 1991. J. Biol. Chem. 266, 4387. Perez-Sala, D., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 3043. Volker, C., et al. 1991. J. Biol. Chem. 266, 21515. Hall, A. 1990. Science 249, 635. Yamane, H.K., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 5868.