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476300 Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem

A potent immunosuppressant.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: ISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid

Primary Target: Serine palmitoyltransferase
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476300
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
35891-70-4C₂₁H₃₉NO₆

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      Description
      OverviewA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
      Catalogue Number476300
      Brand Family Calbiochem®
      SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
      References
      ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.
      Product Information
      CAS number35891-70-4
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₁H₃₉NO₆
      Chemical formulaC₂₁H₃₉NO₆
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSerine palmitoyltransferase
      Primary Target K<sub>i</sub>280 pM against serine palmitoyltransferase
      Purity≥95% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSJX3890000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      476300-5MG 04055977183801

      Documentation

      Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Myriocin, Mycelia sterilia - CAS 35891-70-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      476300

      References

      Reference overview
      Hanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2019 JSW
      SynonymsISP-1, Thermozymocidin, [2S,3R,4R]-(E)-2-Amino-3,4-dihydroxy-2-[hydroxymethyl]-14-oxo-6-eicosenoic Acid
      DescriptionA potent immunosuppressant. Displays 10- to 100-fold more potent immunosuppressant activity than cyclosporin A. Potently inhibits serine palmitoyltransferase (SPT; Ki = 280 pM) thereby blocking the synthesis of ceramide. Disrupts substratum adhesion of melanoma cells. Inhibits cell proliferation and induces apoptosis in IL-2 dependent murine cytotoxic T lymphocyte cell line CTLL-2.
      FormWhite to off-white solid
      CAS number35891-70-4
      RTECSJX3890000
      Chemical formulaC₂₁H₃₉NO₆
      Structure formulaStructure formula
      Purity≥95% by TLC
      SolubilityDMSO (25 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesHanada, K., et al. 2000. Biochem. Pharmacol. 59, 1211.
      Chen, J.K., et al. 1999. Chem. Biol. 6, 221.
      Hidari, K.I.P.J., et al. 1996. J. Biol. Chem. 271, 14636.
      Nakamura, S., et al. 1996. J. Biol. Chem. 271, 1255.
      Mikaye, Y., et al. 1995. Biochem. Biophys. Res. Commun. 211, 396.
      Fujita, T., et al. 1994. J. Antibiot. 47, 208.