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475913 Mycophenolic Acid - CAS 24280-93-1 - Calbiochem

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA

Primary Target: Inosine monophosphate dehydrogenase
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475913
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
24280-93-1C₁₇H₂₀O₆

Pricing & Availability

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475913-100MG
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      475913-500MG
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          Description
          OverviewAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
          Catalogue Number475913
          Brand Family Calbiochem®
          Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
          References
          ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
          Senda, M., et al. 1995. Transplantation 60, 1143.
          Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
          Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
          Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
          Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
          Product Information
          CAS number24280-93-1
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₁₇H₂₀O₆
          Chemical formulaC₁₇H₂₀O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetInosine monophosphate dehydrogenase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSMP8050000
          Safety Information
          R PhraseR: 20/21/22-40

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-36

          Do not breathe dust.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          475913-100MG 04055977184822
          475913-500MG 04055977184150

          Documentation

          Mycophenolic Acid - CAS 24280-93-1 - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          Mycophenolic Acid - CAS 24280-93-1 - Calbiochem Certificates of Analysis

          TitleLot Number
          475913

          References

          Reference overview
          Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
          Senda, M., et al. 1995. Transplantation 60, 1143.
          Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
          Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
          Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
          Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-May-2008 RFH
          Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
          DescriptionAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
          FormWhite to off-white solid
          CAS number24280-93-1
          RTECSMP8050000
          Chemical formulaC₁₇H₂₀O₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityEthanol or 100 mM NaOH (10 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14 6327
          ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
          Senda, M., et al. 1995. Transplantation 60, 1143.
          Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
          Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
          Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
          Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.