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47589 Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem

Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mitocin C, MMC

47589
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      50-07-7C₁₅H₁₈N₄O₅
      Description
      Overview

      This product has been discontinued.



      Antibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues; disrupts base pairing. Forms covalent adducts into deoxyguanine and guanine under acidic conditions. Induces apoptosis in gastric cancer cells. Blocks the cell cycle at the G2 phase.
      Catalogue Number47589
      Brand Family Calbiochem®
      SynonymsMitocin C, MMC
      References
      ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
      Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
      Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
      McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
      Tomasz, M., et al. 1987. Science 235, 1204.
      Product Information
      CAS number50-07-7
      FormBlue-violet solid
      FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
      Hill FormulaC₁₅H₁₈N₄O₅
      Chemical formulaC₁₅H₁₈N₄O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSCN0700000
      Safety Information
      R PhraseR: 28

      Very toxic if swallowed.
      S PhraseS: 36/37-45-28

      Wear suitable protective clothing and gloves.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      47589 0

      Documentation

      Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mitomycin C, Streptomyces caespitosus - CAS 50-07-7 - Calbiochem Certificates of Analysis

      TitleLot Number
      47589

      References

      Reference overview
      Kruyt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
      Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
      Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
      McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
      Tomasz, M., et al. 1987. Science 235, 1204.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision15-May-2008 RFH
      SynonymsMitocin C, MMC
      DescriptionAntibiotic and carcinostatic agent. Inhibits DNA synthesis by cross-linking DNA at guanine and adenine residues, disrupting base pairing. Induces apoptosis in gastic cancer cells. Blocks the cell cycle at the G2 phase.
      FormBlue-violet solid
      FormulationProvided as 2 mg antibiotic and 48 mg NaCl.
      CAS number50-07-7
      RTECSCN0700000
      Chemical formulaC₁₅H₁₈N₄O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C) for short-term storage and in a freezer (-20°C) for longer term. Stock solutions are stable for up to 2 weeks at 4°C and up to 3 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 6215
      ReferencesKruyt, F.A., et al. 1996. Blood 89, 938.
      Schwartz, G.K., et al. 1995. J. Natl. Cancer Inst. 87, 1394.
      Folnan, R.S. 1993. Oncology 50 (Suppl. 1), 24.
      Kawasaki, S., et al. 1992. Jpn. J. Cancer Res. 83, 899.
      Malkinson, A.M., et al. 1992. Cancer Res. 52, 4752.
      McEvoy, J.L., et al. 1992. J. Bacteriol. 174, 5471.
      Tomasz, M., et al. 1987. Science 235, 1204.