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530031 Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Mitochondrial DNA Damaging Agent, mtPt

530031
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₅₈H₁₀₉N₂₂O₁₀Ptplus;
      Description
      Overview

      This product has been discontinued.



      A platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number530031
      Brand Family Calbiochem®
      SynonymsMitochondrial DNA Damaging Agent, mtPt
      References
      ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
      Product Information
      FormWhite powder
      Hill FormulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
      Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Target IC<sub>50</sub>5 µM in cisplatin-resistant A2780CP70 cells
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      530031 0

      Documentation

      Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Mitochondria Targeting Cisplatin Analog, mtPt - Calbiochem Certificates of Analysis

      TitleLot Number
      530031

      References

      Reference overview
      Wisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2014 JSW
      SynonymsMitochondrial DNA Damaging Agent, mtPt
      DescriptionA platinum-based cisplatin analogue (cis-{Pt(NH3)2}2+) conjugated to a mitochondria-penetrating peptide that localizes to mitochondria to induce mitochondrial DNA damage in ovarian cancer cells, but has minimal effect on normal cells. Shown to be effective even in cisplatin-resistant A2780CP70 cells (IC50 = 5.0 µM). Has a much lower resistance factor when compared to cisplatin (0.7 vs 8.7). Exhibits reduced toxicity compared to cisplatin. Diminishes the amplification of the mitochondrial, but not the nuclear DNA segment. Shown to cause a statistically significant reduction in the amplification of the mitochondrial but not nuclear DNA segment, and increases reactive oxygen species (ROS) product.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅₈H₁₀₉N₂₂O₁₀Ptplus;
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml). Use only fresh DMSO for reconstitution.
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
      Toxicity Standard Handling
      ReferencesWisnovsky, S.P., et al. 2013. Chem. Biol. 20, 1323.