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FCMAB205F Milli-Mark™ Anti-CD68-FITC Antibody, clone KP1

This Milli-Mark Anti-CD68-FITC Antibody, clone KP1 is validated for use in FC for the detection of CD68.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P34810
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FCMAB205F
100 tests  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFCMFITCMonoclonal Antibody
      Description
      Catalogue NumberFCMAB205F
      Trade Name
      • Milli-Mark
      DescriptionMilli-Mark™ Anti-CD68-FITC Antibody, clone KP1
      Alternate Names
      • Macrosialin
      • Gp110
      Background InformationCD68 is highly glycosylated lysosomal membrane protein with an Mr of 110,000. The CD68 protein belongs to a family of lysosomal glycoprotein (LGP)/plasma membrane shuttling proteins that play a role in endocytosis and/or lysosomal trafficking. CD68 is expressed strongly in cytoplasmic granules, and weakly on the surface of macrophages, monocytes, neutrophils, basophils, and NK cells. CD68 can also be found in the cytoplasm of non-hematopoietic tissues, especially the liver, and renal glomeruli, and tubules (Goyert, 1997).
      References
      Product Information
      FormatFITC
      Control
      • Human Lymphocytes
      PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
      Quality LevelMQ100
      Applications
      ApplicationThis Milli-Mark Anti-CD68-FITC Antibody, clone KP1 is validated for use in FC for the detection of CD68.
      Key Applications
      • Flow Cytometry
      Biological Information
      ImmunogenLysosomal fraction of human lung macrophages
      CloneKP1
      HostMouse
      SpecificityAntibody recognizes Human CD68 antigen.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryCould play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

      Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.
      Molecular Weight 110 kDa (Goyert, 1997)
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by flow cytometry using human lymphocytes
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
      Packaging Information
      Material Size100 tests
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      FCMAB205F 04053252375460

      Documentation

      Milli-Mark™ Anti-CD68-FITC Antibody, clone KP1 SDS

      Title

      Safety Data Sheet (SDS) 

      Milli-Mark™ Anti-CD68-FITC Antibody, clone KP1 Certificates of Analysis

      TitleLot Number
      Milli-Mark Anti-CD68-FITC, clone KP1 - 2150748 2150748
      Milli-Mark Anti-CD68-FITC, clone KP1 - 2000822 2000822
      Milli-Mark Anti-CD68-FITC, clone KP1 - 2054801 2054801
      Milli-Mark Anti-CD68-FITC, clone KP1 - NRG1775601 NRG1775601
      Milli-Mark™ Anti-CD68-FITC, -2565489 2565489
      Milli-Mark™ Anti-CD68-FITC, -2724440 2724440
      Milli-Mark™ Anti-CD68-FITC, -2740956 2740956
      Milli-Mark™ Anti-CD68-FITC, -2795764 2795764
      Milli-Mark™ Anti-CD68-FITC, clone KP1 - 3222611 3222611
      Milli-Mark™ Anti-CD68-FITC, clone KP1 - 3762738 3762738
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