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475730 MRP1 Inhibitor II, Reversan - Calbiochem

The MRP1 Inhibitor II, Reversan controls the biological activity of MRP1. This small molecule/inhibitor is primarily used for Cell Structure applications.

MRP1 Inhibitor II, Reversan - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Multidrug Resistance Protein 1 Inhibitor, Reversan

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475730
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₇N₅O₂

Pricing & Availability

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475730-10MG
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      Description
      OverviewA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
      Catalogue Number475730
      Brand Family Calbiochem®
      SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
      References
      ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
      Product Information
      FormPale yellow solid
      Hill FormulaC₂₆H₂₇N₅O₂
      Chemical formulaC₂₆H₂₇N₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475730-10MG 04055977185560

      Documentation

      MRP1 Inhibitor II, Reversan - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MRP1 Inhibitor II, Reversan - Calbiochem Certificates of Analysis

      TitleLot Number
      475730

      References

      Reference overview
      Burkhart, C.A., et al. 2009. Cancer Res. 69, 6573.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-December-2010 RFH
      SynonymsMultidrug Resistance Protein 1 Inhibitor, Reversan
      DescriptionA cell-permeable pyrazolopyrimidine that selectively inhibits MRP1. It is shown to increase the efficacy of vincristine and etopiside by 10- to 15-fold and 7- to 10-fold, respectively, over either of these two MRP1 substrate drugs alone in murine models of neuroblastoma (syngenic and human xenografts). As opposed to the majority of inhibitors of multidrug transporters, it is demonstrated that Reversan was not toxic by itself nor did it increase the toxicity of chemotherapeutic drug exposure in mice. Therefore, Reversan represents a new class of nontoxic MRP1 inhibitor, which may be a useful research tool for the study of neuroblastoma and other MRP1-overexpressing drug-refractory tumors.
      FormPale yellow solid
      Chemical formulaC₂₆H₂₇N₅O₂
      Structure formulaStructure formula
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBurkhart, C.A., et al. 2009. Cancer Res. 69, 6573.