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444274 MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem

The MMP-2/MMP-9 Inhibitor IV, also referenced under CAS 292605-14-2, controls the biological activity of MMP-2/MMP-9. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SB-3CT

Primary Target: MMP-2
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444274
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
292605-14-2C₁₅H₁₄O₃S₂

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      		 Plastic ampoule 500 μg
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      Description
      OverviewA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM), and MMP-9 (Ki = 600 nM). This inhibitor appears to behave similarly to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Also exhibits a covalent mechanism-based behavior in inhibition of these enzymes. Binds directly to the catalytic zinc ion on MMP-2.
      Catalogue Number444274
      Brand Family Calbiochem®
      SynonymsSB-3CT
      References
      ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
      Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
      Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
      Product Information
      CAS number292605-14-2
      ATP CompetitiveN
      DeclarationSold under license of U.S. Patent 6,703,415.
      FormOff-white solid
      Hill FormulaC₁₅H₁₄O₃S₂
      Chemical formulaC₁₅H₁₄O₃S₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-2
      Primary Target K<sub>i</sub>13.9 nM
      Purity≥ 95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444274-500UG 04055977186581

      Documentation

      MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      444274

      References

      Reference overview
      Krüger, A., et al. 2005. Cancer Res. 65, 3523.
      Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
      Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-April-2019 JSW
      SynonymsSB-3CT
      DescriptionA potent, selective, slow-binding and mechanism-based inhibitor of human gelatinases, MMP-2 (Ki = 13.9 nM) and MMP-9 (Ki = 600 nM). It also exhibits a covalent mechanism based behavior in inhibition of these enzymes. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. Shown to directly bind to the zinc in the catalytic site of MMP-2. Does not affect the activities of MMP-1 (Ki = 206 µM) MMP-3 (Ki = 15 µM), or MMP-7 (Ki = 96 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number292605-14-2
      Chemical formulaC₁₅H₁₄O₃S₂
      Structure formulaStructure formula
      Purity≥ 95% by HPLC
      SolubilityDMSO (>20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKrüger, A., et al. 2005. Cancer Res. 65, 3523.
      Kleinfeld, O., et al. 2001. J. Biol. Chem. 276, 17125.
      Brown, S., et al. 2000. J. Am. Chem. Soc. 122, 6799.