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475837 MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem

MIF Antagonist, ISO-1, CAS 478336-92-4, is a cell-permeable inhibitor of MIF tautomerase (IC50 = 7 µM for D-dopachrome tautomerase). Suppresses the production of TNFα, PGE2 & COX-2 in monocytes.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1

Primary Target: MIF tautomerize
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475837
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Overview

Key Spec Table

CAS #Empirical Formula
478336-92-4C₁₂H₁₃NO₄

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475837-5MG
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      Description
      OverviewA cell-permeable isoxazoline compound that displays anti-inflammatory properties. Inhibits MIF tautomerase activity by binding to its catalytic active site (IC50 = 7 µM for D-dopachrome tautomerase) and suppresses the production of TNFα, PGE2 and COX-2 in human monocytes, and arachidonic acid in RAW 264.7 macrophages. Shown to exhibit antidiabetogenic properties in immunoinflammatory diabetic mouse model. Also available as a 50 mM solution in DMSO (Cat. No. 505225).
      Catalogue Number475837
      Brand Family Calbiochem®
      Synonyms(S,R)-3-(4-Hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester, Macrophage Migration Inhibitory Factor Antagonist, ISO-1
      References
      ReferencesCvetkovic, I., et al. 2005. Endocrinology, 146, 2942.
      Lubetsky, J.B., et al. 2002. J. Biol. Chem. 277, 24976.
      Product Information
      CAS number478336-92-4
      ATP CompetitiveN
      FormLight yellow solid
      Hill FormulaC₁₂H₁₃NO₄
      Chemical formulaC₁₂H₁₃NO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationMIF Antagonist, ISO-1, CAS 478336-92-4, is a cell-permeable inhibitor of MIF tautomerase (IC50 = 7 µM for D-dopachrome tautomerase). Suppresses the production of TNFα, PGE2 & COX-2 in monocytes.
      Biological Information
      Primary TargetMIF tautomerize
      Primary Target IC<sub>50</sub>7 µM for D-dopachrome tautomerase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      475837-5MG 04055977184969