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12-240 MAPKAP Kinase Substrate Peptide

MAPKAP Kinase Substrate Peptide primarily used in Kinase Assays.

MAPKAP Kinase Substrate Peptide MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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12-240
1 mg  
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      Overview

      Replacement Information
      Description
      Catalogue Number12-240
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMAPKAP Kinase Substrate Peptide
      References
      Product Information
      PresentationLyophilized powder
      Quality LevelMQ300
      Applications
      ApplicationMAPKAP Kinase Substrate Peptide primarily used in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene.
      Gene Symbol
      • MAPKAPK2
      • MK2
      • MAPKAPK-2
      Protein TargetMAPKAP
      Target Sub-FamilyCAMK
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P49137 # Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25). In vitro can phosphorylate glycogen synthase at 'Ser-7' and tyrosine hydroxylase (on 'Ser-19' and 'Ser-40'). This kinase phosphorylates Ser in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue (By similarity). Mediates both ERK and p38 MAPK/MAPK14 dependent neutrophil responses. Participates in TNF alpha-stimulated exocytosis of secretory vesicles in neutrophils. Plays a role in phagocytosis-induced respiratory burst activity.
      SIZE: 400 amino acids; 45568 Da
      SUBUNIT: Interacts with PHC2.
      TISSUE SPECIFICITY: Expressed in all tissues examined.
      PTM: Phosphorylated and activated by MAP kinase.
      SIMILARITY: SwissProt: P49137 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated as a substrate for MAPKAP Kinase 2, active (14-216 & 14-337). May also be used as a substrate for MAPKAP Kinase 1.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsLyophilized: Stable for 2 years at 4°C
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      12-240 04053252335969

      Documentation

      MAPKAP Kinase Substrate Peptide SDS

      Title

      Safety Data Sheet (SDS) 

      MAPKAP Kinase Substrate Peptide Certificates of Analysis

      TitleLot Number
      MAPKAP Kinase Substrate Peptide 2981173
      MAPKAP Kinase Substrate Peptide 2864976
      MAPKAP Kinase Substrate Peptide 3117835
      MAPKAP Kinase Substrate Peptide - 2142598 2142598
      MAPKAP Kinase Substrate Peptide - 2383485 2383485
      MAPKAP Kinase Substrate Peptide - 16519 16519
      MAPKAP Kinase Substrate Peptide - 17120 17120
      MAPKAP Kinase Substrate Peptide - 17363 17363
      MAPKAP Kinase Substrate Peptide - 18844 18844
      MAPKAP Kinase Substrate Peptide - 2073143 2073143
      Show more

      References

      Reference overviewApplicationPub Med ID
      Adenovirus-activated PKA and p38/MAPK pathways boost microtubule-mediated nuclear targeting of virus
      Suomalainen, M., et al
      Embo J, 20:1310-9 (2001)  2001

      		Kinase Assay11250897 11250897
      Motoneuron apoptosis is blocked by CEP-1347 (KT 7515), a novel inhibitor of the JNK signaling pathway
      Maroney, A. C., et al
      J Neurosci, 18:104-11 (1998)  1998

      		Kinase Assay9412490 9412490

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      Categories

      Life Science Research > Proteins and Enzymes > Substrate & Control Proteins > Kinase & Phosphatase Substrates
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Kinase & Phosphatase Substrates