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9016 Lis/Pro Insulin

Iodinated Human Lis/Pro insulin -HPLC purified & prepared fresh monthly.

Lis/Pro Insulin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P01308 Entrez Gene Number: NM_000207.2
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9016
250 tubes  
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      Overview

      Replacement Information
      Description
      Catalogue Number9016
      DescriptionLis/Pro Insulin
      Background InformationThese iodinated hormonos are HPLC purified and prepared fresh monthly.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationIodinated Human Lis/Pro insulin -HPLC purified & prepared fresh monthly.
      Application Notesappropriate label hydrating buffer if kit replacement or assay buffer of choice
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      Radioactive Isotype125Iodine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Physicochemical Information
      Radioactivity<3 μCi
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2–8 °C
      Packaging Information
      Material Size250 tubes
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      9016 04053252326745